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Combination Vaccine Safe & Effective For Infants

by The Kid's Doctor Staff

A combination vaccine against diphtheria, tetanus, pertussis, polio and flu, which is routinely used in Canada has been shown to be effective and well tolerated in a U.S. study.

The randomized trial involving nearly 2,000 infants vaccinated at 2, 4 and 6 months of age was conducted to support U.S. licensure of the vaccine known as DTaP5-IPV-Hib. The vaccine incorporates diphtheria-tetanus-5-component acellular pertussis (DTaP5), inactivated poliovirus (IPV) and Haemophilius influenzae type B (Hib) vaccines.

In the study, the infants were vaccinated with either the DTaP5-IPV-Hib combination vaccine or with the DTaP5, IPV and Hib vaccines separately. Some babies in each group were also given a fourth dose of DTaP5-IPV-Hib or of the DTaP5 and Hib vaccines as toddlers.

In the January 2009 journal Pediatrics, Dr. Fernando A. Guerra of the San Antonio Metropolitan Health District in Texas and colleagues report that compared with licensed vaccines, the combined vaccine was equally effective and produced similar or fewer reactions at the injection site and throughout the body.

“The current results are reassuring and consistent with safety surveillances data in Canada, where for the past decade, the combination vaccine has been the only DTaP-containing vaccine used among infants and toddlers,” the researchers conclude.

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